Assuntos
Dermatite Seborreica , Dermatite , Histiocitose de Células de Langerhans , Hepatopatias , Dermatite Seborreica/diagnóstico , Histiocitose de Células de Langerhans/complicações , Histiocitose de Células de Langerhans/diagnóstico , Humanos , Lactente , Hepatopatias/diagnóstico , Hepatopatias/etiologia , PeleRESUMO
Abstract Monilethrix is a rare defect of the hair shaft, with most cases showing an autosomal dominant pattern of inheritance and variable clinical expression. It is characterized by hypotrichosis secondary to hair fragility. The diagnosis is made through trichoscopy, detecting typical findings such as periodic narrowing at regular intervals, giving the hair the appearance of beads in a rosary. This article reports the case of six members of a family diagnosed with monilethrix with alopecia of varying degrees.
Assuntos
Humanos , Alopecia em Áreas , Doenças do Cabelo , Couro Cabeludo , Alopecia/diagnóstico , Alopecia/genética , CabeloRESUMO
Generalized verrucosis is a clinical manifestation of human papillomavirus infection. Patients with generalized verrucosis present with over 20 verrucae distributed over various anatomical sites. The disorder occurs in association with several genetic syndromes with immunodeficiency, including GATA2 deficiency. We report a 12-year-old boy with GATA2 deficiency and generalized verrucosis that worsened after cyclosporine use following bone marrow transplant. Systemic treatment with acitretin and topical application of trichloroacetic acid, likely along with immune reconstitution, led to complete remission.
Assuntos
Deficiência de GATA2 , Verrugas , Acitretina/uso terapêutico , Criança , Fator de Transcrição GATA2 , Humanos , Masculino , Papillomaviridae , Ácido Tricloroacético , Verrugas/tratamento farmacológicoRESUMO
Monilethrix is a rare defect of the hair shaft, with most cases showing an autosomal dominant pattern of inheritance and variable clinical expression. It is characterized by hypotrichosis secondary to hair fragility. The diagnosis is made through trichoscopy, detecting typical findings such as periodic narrowing at regular intervals, giving the hair the appearance of beads in a rosary. This article reports the case of six members of a family diagnosed with monilethrix with alopecia of varying degrees.
